CCNO

CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include Ciliary Dyskinesia, Primary, 29 and Primary Ciliary Dyskinesia. Gene Ontology (GO) annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCNB1.

Full Name

Cyclin O

Function

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Biological Process

Cell division Source: UniProtKB-KW
Cilium assembly Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic cell cycle phase transition Source: GO_Central
Multi-ciliated epithelial cell differentiation Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Response to drug Source: Ensembl

Cellular Location

Cytoplasm; Nucleolus. Localizes to the apical part of cytoplasm.

Involvement in disease

Ciliary dyskinesia, primary, 29 (CILD29): The disease is caused by variants affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition.