CD80 (extra-cellular domain)

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

CD80 Molecule

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Cell surface receptor signaling pathway Source: GO_Central
Cellular response to lipopolysaccharide Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Immune response Source: GO_Central
Intracellular signal transduction Source: UniProtKB
Negative regulation of T cell proliferation Source: GO_Central
Positive regulation of granulocyte macrophage colony-stimulating factor production Source: UniProtKB
Positive regulation of interleukin-2 production Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein kinase B signaling Source: Reactome
Positive regulation of signal transduction Source: UniProtKB
Positive regulation of T cell proliferation Source: GO_Central
Positive regulation of T-helper 1 cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
T cell costimulation Source: GO_Central

Membrane

Extracellular: 35-242
Helical: 243-263
Cytoplasmic: 264-288