CEP350

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Full Name

Centrosomal Protein 350

Function

Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644).
Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385).
Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782).
Required for ciliation (PubMed:28659385).

Biological Process

Microtubule anchoring Source: InterPro
Non-motile cilium assembly Source: Ensembl
Protein localization to centrosome Source: Ensembl

Cellular Location

Centrosome; Spindle; Centriole; Cilium basal body; Nucleus. Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385).

PTM

Phosphorylated during mitosis.