Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CEP350 Recombinant Antibody (EG649) (CBMAB-EN782-LY)

The product is antibody recognizes CEP350. The antibody EG649 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all CEP350 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG649
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CEP350.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Centrosomal Protein 350
Introduction
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9857
UniProt ID
Q5VT06
Alternative Names
Centrosomal Protein 350; Centrosomal Protein 350kDa; CAP350; Centrosome-Associated Protein Of 350 KDa; Centrosome Associated Protein 350; Centrosome-Associated Protein 350; KIAA0480; Cep350; GM133;
Function
Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644).
Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385).
Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782).
Required for ciliation (PubMed:28659385).
Biological Process
Microtubule anchoring Source: InterPro
Non-motile cilium assembly Source: Ensembl
Protein localization to centrosome Source: Ensembl
Cellular Location
Centrosome; Spindle; Centriole; Cilium basal body; Nucleus. Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385).
PTM
Phosphorylated during mitosis.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CEP350 Recombinant Antibody (EG649)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare