Apoptosis is an autonomous process that leads to programmed cell death to remove unwanted or abnormal cells in organisms and maintains a stable internal environment. Apoptosis mediates the programmed cell death either in a caspase-dependent or in a caspase-independent pathway. Apoptosis occurs normally during development and aging and as a homeostatic mechanism to maintain cell populations in tissues, while cancer cells obtain immortality by escaping programmed cell death. The cancer cells evade apoptosis via various mechanisms, including upregulate anti-apoptotic signals (Bcl-2, Akt, Mcl-1, etc.) and downregulate pro-apoptotic signals (Bax, Bak, Bad, etc.).
Fig.1 The intrinsic and extrinsic apoptotic pathways[1].
Understanding the underlying mechanism of cancer resistance to programmed cell death is fundamental for efficient cancer treatment agents. Creative Biolabs offers cancer-apoptosis-related pathway phosphorylation screening service with antibody array, which consists of 155 high-specific antibodies and more than 70 phosphorylation sites involved in cancer-apoptosis-related pathways can be tested.
Signal Pathways | |
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Targets |
AFX (S197) | HSP27 (S15) | NFKB-p65 (S311) | PRKCD (S645) |
ASK1 (S83) | HSP27 (S78) | NFKB-p65 (S276) | PRKCQ (S676) |
ASK1 (S966) | HSP27 (S82) | NFKB-p65 (S468) | PTEN (S370) |
BAD (S112) | NFKBIA (S32/S36) | NFKB-p65 (S529) | PTEN (S380) |
BAD (S136) | NFKBIA (Y42) | NFKB-p65 (S536) | PTEN (S380/T382/T383) |
BAD (S155) | CHUK (T23) | NFKB-p65 (T254) | Raf1 (S259) |
BCL-2 (S70) | IRS-1 (S307) | NFKB-p65 (T435) | Raf1 (S338) |
BCL-2 (T56) | IRS-1 (S312) | p44/42 MAP Kinase (T202) | rpS6 (S235) |
BCL-XL (S62) | IRS-1 (S636) | p44/42 MAP Kinase (Y204) | Src (Y418) |
CDC2 (Y15) | IRS-1 (S639) | p53 (S15) | Src (Y529) |
cdc25A (S75) | JAK1 (Y1022) | p53 (S315) | STAT1 (S727) |
cdc25C (S216) | JAK2 (Y1007) | p53 (S33) | STAT1 (Y701) |
CDK2 (T160) | JAK2 (Y221) | p53 (S37) | STAT3 (S727) |
CREB (S129) | NFKB-p100/p52 (S865) | p53 (S46) | STAT3 (Y705) |
CREB (S133) | NFKB-p100/p52 (S869) | p53 (S6) | STAT4 (Y693) |
FKHR (S256) | NFKB-p105/p50 (S337) | p53 (S9) | STAT5A (S780) |
FKHR (S319) | NFKB-p105/p50 (S893) | p53 (T18) | STAT5A (Y694) |
FKHRL1 (S253) | NFKB-p105/p50 (S907) | S6K1 (S411) | STAT6 (T645) |
GSK3A (S21) | NFKB-p105/p50 (S932) | S6K1 (S424) | STAT6 (Y641) |
GSK3B (S9) |
For more detailed information about our antibody arrays, please feel free to contact us.
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