CHRNA10

CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and CREB Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.

Full Name

Cholinergic Receptor Nicotinic Alpha 10 Subunit

Function

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Biological Process

Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Ion transmembrane transport Source: GO_Central
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Nervous system process Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: MGI
Regulation of cell population proliferation Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, cholinergic Source: UniProtKB

Cellular Location

Postsynaptic cell membrane; Cell membrane

Topology

Extracellular: 25-237
Helical: 238-258
Helical: 268-288
Helical: 302-322
Cytoplasmic: 323-428
Helical: 429-449