CHRNA10

CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and CREB Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.

Cholinergic Receptor Nicotinic Alpha 10 Subunit

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Ion transmembrane transport Source: GO_Central
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Nervous system process Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: MGI
Regulation of cell population proliferation Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, cholinergic Source: UniProtKB

Postsynaptic cell membrane; Cell membrane

Extracellular: 25-237
Helical: 238-258
Helical: 268-288
Helical: 302-322
Cytoplasmic: 323-428
Helical: 429-449