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Mouse Anti-CHRNA10 Recombinant Antibody (EG685) (CBMAB-EN826-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EG685
Antibody Isotype
IgG1
Application
WB, ELISA, FC

Basic Information

Immunogen
Purified recombinant fragment of human Nicotinic Acetylcholine R alpha 10/CHRNA10 (AA 25-237).
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:2,000
WB1:100-1:2,000
FC1:10-1:1000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cholinergic Receptor Nicotinic Alpha 10 Subunit
Introduction
CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and CREB Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.
Entrez Gene ID
57053
UniProt ID
Q9GZZ6
Alternative Names
Cholinergic Receptor Nicotinic Alpha 10 Subunit; Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal); Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10; Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal); Nicotinic Acetylcholine Receptor Subunit Alpha-10; Cholinergic Receptor, Nicotinic Alpha 10; NACHR Alpha-10; NACHRA10;
Function
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Biological Process
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Ion transmembrane transport Source: GO_Central
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Nervous system process Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: MGI
Regulation of cell population proliferation Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, cholinergic Source: UniProtKB
Cellular Location
Postsynaptic cell membrane; Cell membrane
Topology
Extracellular: 25-237
Helical: 238-258
Helical: 268-288
Helical: 302-322
Cytoplasmic: 323-428
Helical: 429-449
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For research use only. Not intended for any clinical use.

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