COL14A1

COL14A1 (Collagen Type XIV Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL14A1 include Palmoplantar Keratoderma, Punctate Type Ia and Punctate Palmoplantar Keratoderma. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is COL12A1.

Collagen Type XIV Alpha 1 Chain

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).

Cell-cell adhesion Source: UniProtKB
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: UniProtKB

Extracellular matrix

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.