COLEC12

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. In addition, these receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells. [provided by RefSeq]

collectin sub-family member 12

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.

Carbohydrate mediated signaling Source: UniProtKB
Cellular response to exogenous dsRNA Source: UniProtKB
Defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell adhesion molecule production Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Regulation of immune response Source: Reactome
Toll-like receptor 3 signaling pathway Source: UniProtKB

Membrane. Forms clusters on the cell surface.

Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-742