Rat Anti-COLEC12 Recombinant Antibody (C11113) (V2LY-1206-LY715)

Name: Rat Anti-COLEC12 Recombinant Antibody (C11113)
SKU: V2LY-1206-LY715
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

C11113

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Recombinant human CL‑P1/COLEC12 isoform 1 Leu57-Leu742.

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

collectin sub-family member 12

Entrez Gene ID

81035

UniProt ID

Q5KU26

Function

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.

Biological Process

Carbohydrate mediated signaling Source: UniProtKB
Cellular response to exogenous dsRNA Source: UniProtKB
Defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell adhesion molecule production Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Regulation of immune response Source: Reactome
Toll-like receptor 3 signaling pathway Source: UniProtKB

Cellular Location

Membrane. Forms clusters on the cell surface.

Topology

Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-742

More Infomation

References

Li, G. Z., Deng, J. F., Qi, Y. Z., Liu, R., & Liu, Z. X. (2020). COLEC12 regulates apoptosis of osteosarcoma through Toll‐like receptor 4–activated inflammation. Journal of Clinical Laboratory Analysis, 34(11), e23469.

Chang, L. L., Hsu, W. H., Kao, M. C., Chou, C. C., Lin, C. C., Liu, C. J., ... & Huang, S. K. (2018). Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases. Scientific reports, 8(1), 1-10.

Lin, E., Kuo, P. H., Liu, Y. L., Yang, A. C., & Tsai, S. J. (2017). Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population. Oncotarget, 8(55), 93349.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rat Anti-COLEC12 Recombinant Antibody (1412)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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