DEFA5

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Defensin Alpha 5

Defensin Alpha 5; Defensin, Alpha 5, Paneth Cell-Specific; HD5(20-94); DEF5; Defensin, Alpha 5, Preproprotein; Defensin, Alpha 5; Defensin-5; HD-5;

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.

Antibacterial humoral response Source: GO_Central
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: GO_Central
Defense response to fungus Source: UniProtKB-KW
Defense response to Gram-negative bacterium Source: UniProtKB
defense response to Gram-positive bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Innate immune response in mucosa Source: GO_Central
Killing by host of symbiont cells Source: CACAO
Killing of cells of other organism Source: UniProtKB
Membrane disruption in other organism Source: GO_Central
Positive regulation of membrane permeability Source: UniProtKB

Secreted; Secretory vesicle. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.

Glycosylated.