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EHMT2

This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Full Name
EHMT2
Research Area
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Biological Process
Behavioral response to cocaine Source: Ensembl
Cellular response to cocaine Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to starvation Source: MGI
DNA methylation Source: UniProtKB
DNA methylation on cytosine within a CG sequence Source: Ensembl
Fertilization Source: Ensembl
Histone lysine methylation Source: MGI
Histone methylation Source: UniProtKB
Long-term memory Source: Ensembl
Negative regulation of autophagosome assembly Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: MGI
Neuron fate specification Source: Ensembl
Organ growth Source: Ensembl
Peptidyl-lysine dimethylation Source: UniProtKB
Phenotypic switching Source: Ensembl
Regulation of DNA methylation Source: Ensembl
Regulation of DNA replication Source: UniProtKB
Regulation of histone H3-K4 methylation Source: Ensembl
Regulation of histone H3-K9 methylation Source: Ensembl
Response to ethanol Source: Ensembl
Response to fungicide Source: Ensembl
Spermatid development Source: Ensembl
Synaptonemal complex assembly Source: Ensembl
Cellular Location
Nucleus; Chromosome. Associates with euchromatic regions. Does not associate with heterochromatin.
PTM
Methylated at Lys-185; automethylated.

Anti-EHMT2 antibodies

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Target: EHMT2
Host: Hamster
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYE-0628
Application*: WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0627
Application*: IF, WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Horse, Human, Mouse, Pig, Rat
Clone: CBFYE-0625
Application*: IC, IF, WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0624
Application*: WB, P
Target: EHMT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: A8620A
Application*: E, IC, IF, IH, IP, WB
Target: EHMT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3133
Application*: WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Pig
Clone: C6H3
Application*: WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 9j132C6H3
Application*: IF, WB
Target: EHMT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-022
Application*: WB, P
Target: EHMT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D9
Application*: IP, M
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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