EIPR1

EIPR1 acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. It also mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.

EARP Complex And GARP Complex Interacting Protein 1

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922).

Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922).

Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922).

Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity).

Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity).

Endocytic recycling Source: UniProtKB
Positive regulation of endocytic recycling Source: UniProtKB
Positive regulation of retrograde transport, endosome to Golgi Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of insulin secretion Source: UniProtKB

Trans-Golgi network