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Mouse Anti-EIPR1 Recombinant Antibody (CBYJT-1209) (CBMAB-T0223-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to EIPR1 (EARP Complex And GARP Complex Interacting Protein 1). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all EIPR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYJT-1209
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa288-387 from human TSSC1 (NP_003301) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 288-387

Target

Full Name
EARP Complex And GARP Complex Interacting Protein 1
Introduction
EIPR1 acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. It also mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.
Entrez Gene ID
Human7260
Rat362721
UniProt ID
HumanQ53HC9
RatQ5PPK9
Alternative Names
TSSC1; EIPR-1
Research Area
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922).

Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922).

Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922).

Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity).

Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity).
Biological Process
Endocytic recycling Source: UniProtKB
Positive regulation of endocytic recycling Source: UniProtKB
Positive regulation of retrograde transport, endosome to Golgi Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of insulin secretion Source: UniProtKB
Cellular Location
Trans-Golgi network
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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