ELOVL7

ELOVL7 (ELOVL Fatty Acid Elongase 7) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL1.

ELOVL Fatty Acid Elongase 7

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Fatty acid elongation, monounsaturated fatty acid Source: GO_Central
Fatty acid elongation, polyunsaturated fatty acid Source: UniProtKB
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB

Endoplasmic reticulum membrane