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Mouse Anti-ELOVL7 Recombinant Antibody (CBFYE-0169) (CBMAB-E0399-FY)

This product is mouse antibody that recognizes ELOVL7. The antibody CBFYE-0169 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all ELOVL7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0169
Antibody Isotype
IgG
Application
WB, ELISA, IHC

Basic Information

Immunogen
Peptide Sequence-RAYTKGQRLP
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELOVL Fatty Acid Elongase 7
Introduction
ELOVL7 (ELOVL Fatty Acid Elongase 7) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL1.
Entrez Gene ID
79993
UniProt ID
A1L3X0
Alternative Names
ELOVL Fatty Acid Elongase 7; ELOVL Family Member 7, Elongation Of Long Chain Fatty Acids (Yeast); Very Long Chain 3-Ketoacyl-CoA Synthase 7; Very Long Chain 3-Oxoacyl-CoA Synthase 7; 3-Keto Acyl-CoA Synthase ELOVL7; ELOVL FA Elongase 7; EC 2.3.1.199
Research Area
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Biological Process
Fatty acid elongation, monounsaturated fatty acid Source: GO_Central
Fatty acid elongation, polyunsaturated fatty acid Source: UniProtKB
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane

Gorenjak, M., Zupin, M., Jezernik, G., Skok, P., & Potočnik, U. (2021). Omics data integration identifies ELOVL7 and MMD gene regions as novel loci for adalimumab response in patients with Crohn’s disease. Scientific Reports, 11(1), 1-12.

Wernick, A. I., Walton, R. L., Soto-Beasley, A. I., Koga, S., Ren, Y., Heckman, M. G., ... & Ross, O. A. (2021). Investigating ELOVL7 coding variants in multiple system atrophy. Neuroscience letters, 749, 135723.

Shi, H., Wang, L., Luo, J., Liu, J., Loor, J. J., & Liu, H. (2019). Fatty acid elongase 7 (ELOVL7) plays a role in the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. Animals, 9(6), 389.

Mah, M. Q., Kuah, M. K., Ting, S. Y., Merosha, P., Janaranjani, M., Goh, P. T., ... & Shu-Chien, A. C. (2019). Molecular cloning, phylogenetic analysis and functional characterisation of an Elovl7-like elongase from a marine crustacean, the orange mud crab (Scylla olivacea). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 232, 60-71.

Li, G., Cui, S., Du, J., Liu, J., Zhang, P., Fu, Y., ... & Chen, S. (2018). Association of GALC, ZNF184, IL1R2 and ELOVL7 with Parkinson’s disease in southern Chinese. Frontiers in aging neuroscience, 10, 402.

Wang, B., Cheng, M., Kong, M., Zhang, M., Yue, B., & Ge, W. (2018). Effects of dietary folic acid and vitamin B12 on growth performance, slaughter performance, fat deposition and ELOVL7 gene expression level of Wulong goose. Chinese Journal of Animal Nutrition, 30(11), 4433-4443.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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