ENTPD5

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq]

ectonucleoside triphosphate diphosphohydrolase 5

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP> IDP> UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

de novo' posttranslational protein folding Source: UniProtKB
ATP metabolic process Source: UniProtKB
Nucleoside diphosphate catabolic process Source: GO_Central
Positive regulation of glycolytic process Source: UniProtKB
Protein N-linked glycosylation Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB

Endoplasmic reticulum; Secreted

N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.