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Mouse Anti-ENTPD5 Recombinant Antibody (4A5) (CBMAB-A2624-LY)

The product is antibody recognizes ENTPD5. The antibody 4A5 immunoassay techniques such as: WB, ELISA.
See all ENTPD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
ENTPD5 (NP_001240, 319 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ectonucleoside triphosphate diphosphohydrolase 5
Introduction
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq]
Entrez Gene ID
957
UniProt ID
O75356
Alternative Names
CD39L4; MGC163357; MGC163359; NTPDase-5; PCPH
Research Area
Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP> IDP> UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
Biological Process
de novo' posttranslational protein folding Source: UniProtKB
ATP metabolic process Source: UniProtKB
Nucleoside diphosphate catabolic process Source: GO_Central
Positive regulation of glycolytic process Source: UniProtKB
Protein N-linked glycosylation Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Cellular Location
Endoplasmic reticulum; Secreted
PTM
N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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