EPGN

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Epithelial Mitogen

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Angiogenesis Source: HGNC-UCL
Epidermal growth factor receptor signaling pathway Source: GO_Central
Positive regulation of cell population proliferation Source: HGNC-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: HGNC-UCL
Positive regulation of epithelial cell proliferation Source: HGNC-UCL
Positive regulation of MAP kinase activity Source: HGNC-UCL
Positive regulation of mitotic nuclear division Source: HGNC-UCL

Isoform 1&2: Membrane
Isoform 3&4&5&6: Secreted

Extracellular: 23-110
Helical: 111-131
Cytoplasmic: 132-154