ESYT2

ESYT2 (Extended Synaptotagmin 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphatidylinositol binding. An important paralog of this gene is ESYT1.

Extended Synaptotagmin 2

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).

Endocytosis Source: UniProtKB-KW
Endoplasmic reticulum-plasma membrane tethering Source: InterPro
Lipid transport Source: UniProtKB-KW

Endoplasmic reticulum membrane; Cell membrane. Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).

Cytoplasmic: 1-103
Helical: 104-124
Lumenal: 125-127
Helical: 128-148
Cytoplasmic: 149-921