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Mouse Anti-ESYT2 Recombinant Antibody (CBFYE-1319) (CBMAB-E1927-FY)

This product is mouse antibody that recognizes ESYT2. The antibody CBFYE-1319 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all ESYT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1319
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Extended Synaptotagmin 2
Introduction
ESYT2 (Extended Synaptotagmin 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphatidylinositol binding. An important paralog of this gene is ESYT1.
Entrez Gene ID
UniProt ID
Alternative Names
Extended Synaptotagmin 2; Family With Sequence Similarity 62 (C2 Domain Containing), Member B; CHR2SYT; FAM62B; E-Syt2; Extended Synaptotagmin-Like Protein 2
Research Area
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).
Biological Process
Endocytosis Source: UniProtKB-KW
Endoplasmic reticulum-plasma membrane tethering Source: InterPro
Lipid transport Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Cell membrane. Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).
Topology
Cytoplasmic: 1-103
Helical: 104-124
Lumenal: 125-127
Helical: 128-148
Cytoplasmic: 149-921
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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