EXD1

EXD1 (Exonuclease 3'-5' Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5 exonuclease activity.

Exonuclease 3'-5' Domain Containing 1

RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity).

The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).

Gene silencing by RNA Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Nucleic acid phosphodiester bond hydrolysis Source: GOC
piRNA metabolic process Source: UniProtKB

Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.