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Mouse Anti-EXD1 Recombinant Antibody (CBFYE-1379) (CBMAB-E1997-FY)

This product is mouse antibody that recognizes EXD1. The antibody CBFYE-1379 can be used for immunoassay techniques such as: WB, IF, FC.
See all EXD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey
Clone
CBFYE-1379
Antibody Isotype
IgG1
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human EXD1 produced in HEK293T cell
Specificity
Human, Rat, Monkey
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.6 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Exonuclease 3'-5' Domain Containing 1
Introduction
EXD1 (Exonuclease 3'-5' Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5 exonuclease activity.
Entrez Gene ID
Human161829
Rat311334
Monkey705364
UniProt ID
HumanQ8NHP7
RatD4AD21
MonkeyA0A2K5WI08
Alternative Names
Exonuclease 3'-5' Domain Containing 1; Exonuclease 3-5 Domain Containing 1; Exonuclease 3-5 Domain-Like-Containing Protein 1; Exonuclease 3-5 Domain-Containing Protein 1; Inactive Exonuclease EXD1; EXDL1; Exonuclease 3-5 Domain-Like 1; PiRNA Biogenesis Protein EXD1
Research Area
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity).

The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).
Biological Process
Gene silencing by RNA Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Nucleic acid phosphodiester bond hydrolysis Source: GOC
piRNA metabolic process Source: UniProtKB
Cellular Location
Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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