FBXL17

Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM

F-box and leucine-rich repeat protein 17

Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310).

FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310).

The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity).

The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310).

The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298).

The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).

Entrainment of circadian clock by photoperiod Source: GO_Central
G2/M transition of mitotic cell cycle Source: GO_Central
Nervous system development Source: UniProtKB
Neural crest cell differentiation Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein quality control for misfolded or incompletely synthesized proteins Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of smoothened signaling pathway Source: UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

Nucleus; Cytoplasm. Present in the cytoplasm and nucleus; more abundant in the cytoplasm.