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Mouse Anti-FBXL17 Recombinant Antibody (CBXF-3759) (CBMAB-F1774-CQ)

This product is a mouse antibody that recognizes FBXL17. The antibody CBXF-3759 can be used for immunoassay techniques such as: ELISA.
See all FBXL17 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cat
Clone
CBXF-3759
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
FBXL17 (NP_073735, 194 a.a.-304 a.a) partial recombinant protein
Specificity
Human, Cat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 17
Introduction
Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Entrez Gene ID
Human64839
Cat101093990
UniProt ID
HumanQ9UF56
CatA0A337SSP7
Alternative Names
F-Box And Leucine Rich Repeat Protein 17; F-Box Only Protein 13; FBXO13; Fbl17; Fbx13; F-Box And Leucine-Rich Repeat Protein 17; F-Box/LRR-Repeat Protein 17;
Research Area
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310).

FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310).

The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity).

The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310).

The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298).

The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).
Biological Process
Entrainment of circadian clock by photoperiod Source: GO_Central
G2/M transition of mitotic cell cycle Source: GO_Central
Nervous system development Source: UniProtKB
Neural crest cell differentiation Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein quality control for misfolded or incompletely synthesized proteins Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of smoothened signaling pathway Source: UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Present in the cytoplasm and nucleus; more abundant in the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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