FERMT2

FERMT2 (Fermitin Family Member 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3, 4, 5-trisphosphate binding. An important paralog of this gene is FERMT1.

FERMITIN FAMILY MEMBER 2

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Adherens junction maintenance Source: ARUK-UCL
Cell adhesion Source: ARUK-UCL
Cell-matrix adhesion Source: UniProtKB
Focal adhesion assembly Source: ARUK-UCL
Integrin activation Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Limb development Source: Ensembl
Negative regulation of cell death Source: ARUK-UCL
Negative regulation of fat cell differentiation Source: ARUK-UCL
Negative regulation of vascular permeability Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of epithelial to mesenchymal transition Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of focal adhesion assembly Source: ARUK-UCL
Positive regulation of GTPase activity Source: ARUK-UCL
Positive regulation of integrin activation Source: ARUK-UCL
Positive regulation of mesenchymal stem cell proliferation Source: ARUK-UCL
Positive regulation of myosin light chain kinase activity Source: ARUK-UCL
Positive regulation of osteoblast differentiation Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of protein localization to nucleus Source: ARUK-UCL
Positive regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of substrate adhesion-dependent cell spreading Source: ARUK-UCL
Positive regulation of wound healing, spreading of epidermal cells Source: ARUK-UCL
Protein localization to cell junction Source: ARUK-UCL
Protein localization to membrane Source: UniProtKB
Regulation of cell morphogenesis Source: ARUK-UCL
Regulation of cell shape Source: UniProtKB-KW
Substrate adhesion-dependent cell spreading Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB

Nucleus; Lamellipodium membrane; Cytoskeleton; Stress fiber; Cytoplasm; Cell cortex; Focal adhesion; Membrane; I band; Cell surface. Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.