FGD2

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system.

FYVE, RhoGEF And PH Domain Containing 2

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).

Actin cytoskeleton organization Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Filopodium assembly Source: UniProtKB
Positive regulation of JUN kinase activity Source: Ensembl
Regulation of cell shape Source: UniProtKB
Regulation of GTPase activity Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome

Nucleus; Ruffle membrane; Cytoskeleton; Cytoplasm; Early endosome; Early endosome membrane. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.