Sign in or Register   Sign in or Register
  |  

Rabbit Anti-FGD2 Recombinant Antibody (CBXF-1132) (CBMAB-F0854-CQ)

This product is a rabbit antibody that recognizes FGD2. The antibody CBXF-1132 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all FGD2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1132
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.173 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FYVE, RhoGEF And PH Domain Containing 2
Introduction
The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system.
Entrez Gene ID
Human221472
Mouse26382
Rat309653
UniProt ID
HumanQ7Z6J4
MouseQ8BY35
RatD3Z9I3
Alternative Names
FYVE, RhoGEF And PH Domain Containing 2; Zinc Finger FYVE Domain-Containing Protein 4; FGD1 Family, Member 2; ZFYVE4; FYVE, RhoGEF And PH Domain-Containing Protein 2; FLJ00276 Protein;
Research Area
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Filopodium assembly Source: UniProtKB
Positive regulation of JUN kinase activity Source: Ensembl
Regulation of cell shape Source: UniProtKB
Regulation of GTPase activity Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Nucleus; Ruffle membrane; Cytoskeleton; Cytoplasm; Early endosome; Early endosome membrane. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-FGD2 Recombinant Antibody (CBXF-1132)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare