FGF20

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.

Fibroblast Growth Factor 20

Neurotrophic factor that regulates central nervous development and function.

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Inner ear receptor cell differentiation Source: Ensembl
Negative regulation of neuron apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cardiac muscle cell proliferation Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of dopamine secretion Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc

Secreted

Renal hypodysplasia/aplasia 2 (RHDA2):
A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.