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Mouse Anti-FGF20 Recombinant Antibody (CBXF-1741) (CBMAB-F3276-CQ)

This product is a mouse antibody that recognizes FGF20. The antibody CBXF-1741 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FGF20 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXF-1741
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 20
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.
Entrez Gene ID
Human26281
Mouse80857
Rat66017
UniProt ID
HumanQ9NP95
MouseQ9ESL9
RatQ9EST9
Alternative Names
Fibroblast Growth Factor 20; FGF-20; RHDA2;
Research Area
Neurotrophic factor that regulates central nervous development and function.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Inner ear receptor cell differentiation Source: Ensembl
Negative regulation of neuron apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cardiac muscle cell proliferation Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of dopamine secretion Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Renal hypodysplasia/aplasia 2 (RHDA2):
A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.

Chen, Y., An, N., Zhou, X., Mei, L., Sui, Y., Chen, G., ... & Wang, X. (2022). Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway. Cell death & disease, 13(3), 1-12.

Chiang, H. L., Wu, Y. R., Chen, Y. C., Fung, H. C., & Chen, C. M. (2021). Fibroblast growth factor 20 gene polymorphism in Parkinson’s disease in Asian population: a meta-analysis. Genes, 12(5), 674.

Fletcher, E. J., Jamieson, A. D., Williams, G., Doherty, P., & Duty, S. (2019). Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats. Scientific reports, 9(1), 1-9.

Wang, A. Q., Kong, L. N., Meng, M. Z., Zhao, X. H., Chen, S., & Wang, X. T. (2019). Mechanisms by which fibroblast growth factor 20 improves motor performance in a mouse model of Parkinson’s disease. Neural Regeneration Research, 14(8), 1438.

Boshoff, E. L., Fletcher, E. J., & Duty, S. (2018). Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner. Neuropharmacology, 137, 156-163.

Sadhukhan, D., Das, G., Biswas, A., Ghosh, S., Das, S. K., Ray, K., & Ray, J. (2018). Evaluation of FGF 20 variants for susceptibility to Parkinson’s disease in Eastern Indians. Neuroscience Letters, 675, 68-73.

Jiménez, K. M., Pereira-Morales, A. J., Adan, A., Lopez-Leon, S., & Forero, D. A. (2018). Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene. Molecular Brain, 11(1), 1-4.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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