FOLR2

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq]

folate receptor 2 (fetal)

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Cell adhesion Source: GO_Central
Folate import across plasma membrane Source: InterPro
Folic acid transport Source: UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilization Source: GO_Central
Inflammatory response Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Sperm-egg recognition Source: GO_Central

Secreted; Cell membrane

N-glycosylated.