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Rabbit Anti-FOLR2 Recombinant Antibody (CBXF-1892) (CBMAB-F3423-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1892
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse FOLR1 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
folate receptor 2 (fetal)
Introduction
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
Entrez Gene ID
2350
UniProt ID
P14207
Alternative Names
Folate Receptor Beta; Folate Receptor, Fetal/Placental; Placental Folate-Binding Protein; Folate Receptor 2 (Fetal); FR-BETA; FBP;
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Biological Process
Cell adhesion Source: GO_Central
Folate import across plasma membrane Source: InterPro
Folic acid transport Source: UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilization Source: GO_Central
Inflammatory response Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Sperm-egg recognition Source: GO_Central
Cellular Location
Secreted; Cell membrane
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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