FOXF1

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq]

forkhead box F1

Probable transcription activator for a number of lung-specific genes.

Animal organ morphogenesis Source: GO_Central
Blood vessel development Source: DFLAT
Cardiac left ventricle morphogenesis Source: DFLAT
Cell-cell adhesion Source: Ensembl
Cellular response to cytokine stimulus Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Detection of wounding Source: Ensembl
Determination of left/right symmetry Source: Ensembl
Digestive tract development Source: DFLAT
Ductus arteriosus closure Source: DFLAT
Embryonic digestive tract morphogenesis Source: DFLAT
Embryonic ectodermal digestive tract morphogenesis Source: DFLAT
Embryonic foregut morphogenesis Source: Ensembl
Endocardial cushion development Source: DFLAT
Epithelial cell differentiation involved in mammary gland alveolus development Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Establishment of epithelial cell apical/basal polarity Source: Ensembl
Extracellular matrix organization Source: Ensembl
Heart development Source: DFLAT
In utero embryonic development Source: DFLAT
Lateral mesodermal cell differentiation Source: Ensembl
Lung alveolus development Source: Ensembl
Lung development Source: DFLAT
Lung lobe morphogenesis Source: Ensembl
Lung vasculature development Source: DFLAT
Mesenchyme migration Source: Ensembl
Midgut development Source: DFLAT
Morphogenesis of a branching structure Source: DFLAT
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Pancreas development Source: DFLAT
Positive regulation of cell migration Source: Ensembl
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of mesenchymal cell proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory tube development Source: DFLAT
Right lung morphogenesis Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Smooth muscle cell differentiation Source: Ensembl
Somitogenesis Source: Ensembl
Trachea development Source: DFLAT
Ureter development Source: DFLAT
Vasculogenesis Source: Ensembl
Venous blood vessel development Source: DFLAT

Nucleus

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV):
A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.