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Rabbit Anti-FOXF1 Recombinant Antibody (CBXF-1255) (CBMAB-F0949-CQ)

This product is a rabbit antibody that recognizes FOXF1. The antibody CBXF-1255 can be used for immunoassay techniques such as: WB, FC, IF.
See all FOXF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1255
Antibody Isotype
IgG
Application
WB, FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
forkhead box F1
Introduction
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.
Entrez Gene ID
2294
UniProt ID
Q12946
Alternative Names
Forkhead Box F1; Forkhead-Related Transcription Factor 1; Forkhead-Related Protein FKHL5; Forkhead-Related Activator 1; FREAC-1; FREAC1;
Function
Probable transcription activator for a number of lung-specific genes.
Biological Process
Animal organ morphogenesis Source: GO_Central
Blood vessel development Source: DFLAT
Cardiac left ventricle morphogenesis Source: DFLAT
Cell-cell adhesion Source: Ensembl
Cellular response to cytokine stimulus Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Detection of wounding Source: Ensembl
Determination of left/right symmetry Source: Ensembl
Digestive tract development Source: DFLAT
Ductus arteriosus closure Source: DFLAT
Embryonic digestive tract morphogenesis Source: DFLAT
Embryonic ectodermal digestive tract morphogenesis Source: DFLAT
Embryonic foregut morphogenesis Source: Ensembl
Endocardial cushion development Source: DFLAT
Epithelial cell differentiation involved in mammary gland alveolus development Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Establishment of epithelial cell apical/basal polarity Source: Ensembl
Extracellular matrix organization Source: Ensembl
Heart development Source: DFLAT
In utero embryonic development Source: DFLAT
Lateral mesodermal cell differentiation Source: Ensembl
Lung alveolus development Source: Ensembl
Lung development Source: DFLAT
Lung lobe morphogenesis Source: Ensembl
Lung vasculature development Source: DFLAT
Mesenchyme migration Source: Ensembl
Midgut development Source: DFLAT
Morphogenesis of a branching structure Source: DFLAT
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Pancreas development Source: DFLAT
Positive regulation of cell migration Source: Ensembl
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of mesenchymal cell proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory tube development Source: DFLAT
Right lung morphogenesis Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Smooth muscle cell differentiation Source: Ensembl
Somitogenesis Source: Ensembl
Trachea development Source: DFLAT
Ureter development Source: DFLAT
Vasculogenesis Source: Ensembl
Venous blood vessel development Source: DFLAT
Cellular Location
Nucleus
Involvement in disease
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV):
A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.

Wang, G., Wen, B., Deng, Z., Zhang, Y., Kolesnichenko, O. A., Ustiyan, V., ... & Kalinichenko, V. V. (2022). Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling. Nature Communications, 13(1), 2080.

Braeuer, R. R., Walker, N. M., Misumi, K., Mazzoni-Putman, S., Aoki, Y., Liao, R., ... & Lama, V. N. (2021). Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis. The Journal of Clinical Investigation, 131(21).

Milewski, D., Shukla, S., Gryder, B. E., Pradhan, A., Donovan, J., Sudha, P., ... & Kalin, T. V. (2021). FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene, 40(12), 2182-2199.

Shen, G., Ren, H., Shang, Q., Zhao, W., Zhang, Z., Yu, X., ... & Jiang, X. (2020). Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt/β-catenin signalling pathway and prevents ovariectomy-induced bone loss. EBioMedicine, 52, 102626.

Pradhan, A., Dunn, A., Ustiyan, V., Bolte, C., Wang, G., Whitsett, J. A., ... & Kalinichenko, V. V. (2019). The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia. American journal of respiratory and critical care medicine, 200(8), 1045-1056.

Ren, X., Ustiyan, V., Guo, M., Wang, G., Bolte, C., Zhang, Y., ... & Kalinichenko, V. V. (2019). Postnatal alveologenesis depends on FOXF1 signaling in c-KIT+ endothelial progenitor cells. American journal of respiratory and critical care medicine, 200(9), 1164-1176.

Black, M., Milewski, D., Le, T., Ren, X., Xu, Y., Kalinichenko, V. V., & Kalin, T. V. (2018). FOXF1 inhibits pulmonary fibrosis by preventing CDH2-CDH11 cadherin switch in myofibroblasts. Cell reports, 23(2), 442-458.

Wang, S., Xiao, Z., Hong, Z., Jiao, H., Zhu, S., Zhao, Y., ... & Ding, Y. (2018). FOXF1 promotes angiogenesis and accelerates bevacizumab resistance in colorectal cancer by transcriptionally activating VEGFA. Cancer letters, 439, 78-90.

Ran, L., Chen, Y., Sher, J., Wong, E. W., Murphy, D., Zhang, J. Q., ... & Chi, P. (2018). FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal TumorFOXF1 Defines the Core-Regulatory Circuitry in GIST. Cancer discovery, 8(2), 234-251.

Ustiyan, V., Bolte, C., Zhang, Y., Han, L., Xu, Y., Yutzey, K. E., ... & Kalinichenko, V. V. (2018). FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Developmental biology, 443(1), 50-63.

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For research use only. Not intended for any clinical use.

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