GFER

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (H

Growth Factor, Augmenter Of Liver Regeneration

Isoform 1:
FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.

Isoform 2:
May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Liver development Source: GO_Central

Isoform 1: Mitochondrion intermembrane space; Mitochondrion
Isoform 2: Secreted; Cytoplasm

Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD):
A disease characterized by progressive myopathy and partial combined respiratory-chain deficiency, congenital cataract, sensorineural hearing loss, and developmental delay.