Sign in or Register   Sign in or Register
  |  

Mouse Anti-GFER Recombinant Antibody (829812) (CBMAB-G0364-LY)

This product is antibody recognizes GFER. The antibody 829812 immunoassay techniques such as: WB.
See all GFER antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
829812
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human GFER/ALR, Arg82-Asp205, Accession # P55789
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Factor, Augmenter Of Liver Regeneration
Introduction
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2671
UniProt ID
P55789
Alternative Names
Growth Factor; Augmenter Of Liver Regeneration; FAD-Linked Sulfhydryl Oxidase ALR; HERV1; ALR; HPO; Growth Factor; Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Hepatic Regenerative Stimulation Substance; Augmenter Of Liver Regeneration; ERV1 Homolog (S. Cerevisiae); Erv1-Like Growth Factor;
Function
Isoform 1:
FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.

Isoform 2:
May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Biological Process
Liver development Source: GO_Central
Cellular Location
Isoform 1: Mitochondrion intermembrane space; Mitochondrion
Isoform 2: Secreted; Cytoplasm
Involvement in disease
Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD):
A disease characterized by progressive myopathy and partial combined respiratory-chain deficiency, congenital cataract, sensorineural hearing loss, and developmental delay.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GFER Recombinant Antibody (829812)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare