Mouse Anti-GFER Recombinant Antibody (829812) (CBMAB-G0364-LY)

Name: Mouse Anti-GFER Recombinant Antibody (829812)
SKU: CBMAB-G0364-LY
Rating: 5 (1 reviews)

See all GFER antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

829812

Application

Immunogen

E. coli-derived recombinant human GFER/ALR, Arg82-Asp205, Accession # P55789

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Buffer

Trehalose

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Growth Factor, Augmenter Of Liver Regeneration

Introduction

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2671

UniProt ID

P55789

Alternative Names

Growth Factor; Augmenter Of Liver Regeneration; FAD-Linked Sulfhydryl Oxidase ALR; HERV1; ALR; HPO; Growth Factor; Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Hepatic Regenerative Stimulation Substance; Augmenter Of Liver Regeneration; ERV1 Homolog (S. Cerevisiae); Erv1-Like Growth Factor;

Function

Isoform 1:
FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.

Isoform 2:
May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Biological Process

Liver development Source: GO_Central

Cellular Location

Isoform 1: Mitochondrion intermembrane space; Mitochondrion
Isoform 2: Secreted; Cytoplasm

Involvement in disease

Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD):
A disease characterized by progressive myopathy and partial combined respiratory-chain deficiency, congenital cataract, sensorineural hearing loss, and developmental delay.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GFER Recombinant Antibody (829812)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry