GNMT

The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644.

Glycine N-Methyltransferase

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.

Cellular protein modification process Source: UniProtKB
Glycogen metabolic process Source: Ensembl
Methionine metabolic process Source: Ensembl
Methylation Source: UniProtKB-KW
One-carbon metabolic process Source: GO_Central
Protein homotetramerization Source: UniProtKB
Regulation of gluconeogenesis Source: GO_Central
S-adenosylhomocysteine metabolic process Source: GO_Central
S-adenosylmethionine metabolic process Source: UniProtKB
Sarcosine metabolic process Source: GO_Central

Cytoplasm

Glycine N-methyltransferase deficiency (GNMT deficiency):
The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.