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HBS1L

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Full Name
Hbs1-like (S. cerevisiae)
Function
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132).

In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132).

Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132).

Isoform 2:
Facilitates the association of the exosome complex with the SKI complex.
Biological Process
Signal transduction Source: ProtInc
Translation Source: GO_Central
Cellular Location
Isoform 2: Cytoplasm
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Anti-HBS1L antibodies

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Mouse Anti-HBS1L (AA 1-260) Recombinant Antibody (CBFYH-0760) (CBMAB-H1665-FY)

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Target: HBS1L
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0760
Application*: P
Datasheet SDS

Mouse Anti-HBS1L (AA 1-242) Recombinant Antibody (CBFYH-0759) (CBMAB-H1664-FY)

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Target: HBS1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYH-0759
Application*: WB
Datasheet SDS

Mouse Anti-HBS1L (AA 1-260) Recombinant Antibody (CBFYH-0758) (CBMAB-H1663-FY)

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Target: HBS1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYH-0758
Application*: WB
Datasheet SDS

Mouse Anti-HBS1L (AA 1-260) Recombinant Antibody (CBFYH-0757) (CBMAB-H1662-FY)

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Target: HBS1L
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0757
Application*: WB, IH
Datasheet SDS

Mouse Anti-HBS1L (AA 1-260) Recombinant Antibody (CBFYH-0756) (CBMAB-H1661-FY)

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Target: HBS1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0756
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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