HTR1A

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.

Full Name

5-hydroxytryptamine receptor 1A

Biological Process

Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
Behavioral fear response Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Exploration behavior Source: UniProtKB
Gamma-aminobutyric acid signaling pathway Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Regulation of behavior Source: InterPro
Regulation of dopamine metabolic process Source: UniProtKB
Regulation of hormone secretion Source: InterPro
Regulation of serotonin secretion Source: UniProtKB
Regulation of vasoconstriction Source: InterPro
Serotonin metabolic process Source: UniProtKB
Serotonin receptor signaling pathway Source: UniProtKB

Cellular Location

Cell membrane; Dendrite

Involvement in disease

Periodic fever, menstrual cycle-dependent (PFMC):
A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.

Topology

Extracellular: 1-36
Helical: 37-62
Cytoplasmic: 63-73
Helical: 74-98
Extracellular: 99-110
Helical: 111-132
Cytoplasmic: 133-152
Helical: 153-178
Extracellular: 179-191
Helical: 192-217
Cytoplasmic: 218-345
Helical: 346-367
Extracellular: 368-378
Helical: 379-403
Cytoplasmic: 404-422