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Mouse Anti-HTR1A Recombinant Antibody (CBXS-2386) (CBMAB-S5144-CQ)

This product is a mouse antibody that recognizes HTR1A. The antibody CBXS-2386 can be used for immunoassay techniques such as: IHC, WB.
See all HTR1A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXS-2386
Antibody Isotype
IgM, κ
Application
IHC, WB

Basic Information

Immunogen
Linear peptide corresponding to rat Serotonin Receptor 1A, conjugated to KLH ( NP_036717)
Specificity
Human, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 1A
Introduction
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
Entrez Gene ID
Human3350
Rat24473
UniProt ID
HumanP08908
RatP19327
Alternative Names
5-Hydroxytryptamine Receptor 1A; 5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled; ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A; G-21;
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Biological Process
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
Behavioral fear response Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Exploration behavior Source: UniProtKB
Gamma-aminobutyric acid signaling pathway Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Regulation of behavior Source: InterPro
Regulation of dopamine metabolic process Source: UniProtKB
Regulation of hormone secretion Source: InterPro
Regulation of serotonin secretion Source: UniProtKB
Regulation of vasoconstriction Source: InterPro
Serotonin metabolic process Source: UniProtKB
Serotonin receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Dendrite
Involvement in disease
Periodic fever, menstrual cycle-dependent (PFMC):
A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.
Topology
Extracellular: 1-36
Helical: 37-62
Cytoplasmic: 63-73
Helical: 74-98
Extracellular: 99-110
Helical: 111-132
Cytoplasmic: 133-152
Helical: 153-178
Extracellular: 179-191
Helical: 192-217
Cytoplasmic: 218-345
Helical: 346-367
Extracellular: 368-378
Helical: 379-403
Cytoplasmic: 404-422

Hernández-Díaz, Y., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Juárez-Rojop, I. E., Genis-Mendoza, A. D., López-Narváez, M. L., ... & González-Castro, T. B. (2023). Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. European Archives of Psychiatry and Clinical Neuroscience, 273(1), 5-14.

Szurpnicka, A., Wrońska, A. K., Bus, K., Kozińska, A., Jabłczyńska, R., Szterk, A., & Lubelska, K. (2022). Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera). Journal of Ethnopharmacology, 298, 115604.

Liu, Q., Sun, H., Liu, Y., Li, X., Xu, B., Li, L., & Jin, W. (2022). HTR1A Inhibits the Progression of Triple‐Negative Breast Cancer via TGF‐β Canonical and Noncanonical Pathways. Advanced Science, 9(12), 2105672.

Xu, Z., Gao, C., Tan, T., Jiang, W., Wang, T., Chen, Z., ... & Yuan, Y. (2022). Combined HTR1A/1B methylation and human functional connectome to recognize patients with MDD. Psychiatry Research, 317, 114842.

Xu, Z., Chen, Z., Shen, T., Chen, L., Tan, T., Gao, C., ... & Zhang, Z. (2022). The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy. Psychiatry and Clinical Neurosciences, 76(2), 51-57.

Zhou, S., Shen, Y., Zang, S., Yin, X., & Li, P. (2021). The epigenetic role of HTR1A antagonist in facilitating GnRH expression for pubertal initiation control. Molecular Therapy-Nucleic Acids, 25, 198-206.

Grubor, M., Zivkovic, M., Sagud, M., Nikolac Perkovic, M., Mihaljevic-Peles, A., Pivac, N., ... & Svob Strac, D. (2020). HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms and extrapyramidal side effects in haloperidol-treated patients with schizophrenia. International Journal of Molecular Sciences, 21(7), 2345.

Yoshikawa, A., Li, J., & Meltzer, H. Y. (2020). A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: Confirmation with meta-analysis of other antipsychotic drugs. The pharmacogenomics journal, 20(2), 260-270.

Xie, L., Chen, J., Ding, Y. M., Gui, X. W., Wu, L. X., Tian, S., & Wu, W. (2019). MicroRNA-26a-2 maintains stress resiliency and antidepressant efficacy by targeting the serotonergic autoreceptor HTR1A. Biochemical and biophysical research communications, 511(2), 440-446.

Wang, P., Lv, Q., Mao, Y., Zhang, C., Bao, C., Sun, H., ... & Fang, Y. (2018). HTR1A/1B DNA methylation may predict escitalopram treatment response in depressed Chinese Han patients. Journal of Affective Disorders, 228, 222-228.

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For research use only. Not intended for any clinical use.

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