HTR2A

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

5-Hydroxytryptamine Receptor 2A

Activation of phospholipase C activity Source: UniProtKB
Aging Source: Ensembl
Artery smooth muscle contraction Source: Ensembl
Behavioral response to cocaine Source: Ensembl
Cell death Source: Ensembl
Cellular calcium ion homeostasis Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Memory Source: Ensembl
Negative regulation of potassium ion transport Source: Ensembl
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Positive regulation of glycolytic process Source: Ensembl
Positive regulation of MAP kinase activity Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Positive regulation of vasoconstriction Source: Ensembl
Protein localization to cytoskeleton Source: Ensembl
Regulation of dopamine secretion Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to xenobiotic stimulus Source: UniProtKB
Serotonin receptor signaling pathway Source: ProtInc
Sleep Source: Ensembl
Temperature homeostasis Source: Ensembl
Urinary bladder smooth muscle contraction Source: Ensembl

Cell membrane; Dendrite; Axon; Cytoplasmic vesicle; Caveola; Presynapse

Extracellular: 1-75
Helical: 76-99
Cytoplasmic: 100-110
Helical: 111-132
Extracellular: 133-148
Helical: 149-171
Cytoplasmic: 172-191
Helical: 192-215
Extracellular: 216-233
Helical: 234-254
Cytoplasmic: 255-324
Helical: 325-346
Extracellular: 347-362
Helical: 363-384
Cytoplasmic: 385-471