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Rabbit Anti-HTR2A Recombinant Antibody (EG1588) (CBMAB-EN1901-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1588
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human 5-HT-2A.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 2A
Introduction
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Entrez Gene ID
3356
UniProt ID
P28223
Alternative Names
5-Hydroxytryptamine Receptor 2A; 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled; HTR2; 5-Hydroxytryptamine (Serotonin) Receptor 2A; Serotonin 5-HT-2A Receptor; Serotonin Receptor 2A;
Biological Process
Activation of phospholipase C activity Source: UniProtKB
Aging Source: Ensembl
Artery smooth muscle contraction Source: Ensembl
Behavioral response to cocaine Source: Ensembl
Cell death Source: Ensembl
Cellular calcium ion homeostasis Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Memory Source: Ensembl
Negative regulation of potassium ion transport Source: Ensembl
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Positive regulation of glycolytic process Source: Ensembl
Positive regulation of MAP kinase activity Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Positive regulation of vasoconstriction Source: Ensembl
Protein localization to cytoskeleton Source: Ensembl
Regulation of dopamine secretion Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to xenobiotic stimulus Source: UniProtKB
Serotonin receptor signaling pathway Source: ProtInc
Sleep Source: Ensembl
Temperature homeostasis Source: Ensembl
Urinary bladder smooth muscle contraction Source: Ensembl
Cellular Location
Cell membrane; Dendrite; Axon; Cytoplasmic vesicle; Caveola; Presynapse
Topology
Extracellular: 1-75
Helical: 76-99
Cytoplasmic: 100-110
Helical: 111-132
Extracellular: 133-148
Helical: 149-171
Cytoplasmic: 172-191
Helical: 192-215
Extracellular: 216-233
Helical: 234-254
Cytoplasmic: 255-324
Helical: 325-346
Extracellular: 347-362
Helical: 363-384
Cytoplasmic: 385-471
More Infomation

Bousman, C. A., Stevenson, J. M., Ramsey, L. B., Sangkuhl, K., Hicks, J. K., Strawn, J. R., ... & Bishop, J. R. (2023). Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants. Clinical Pharmacology & Therapeutics.

Wang, Z., Yan, C., Du, Q., Huang, Y., Li, X., Zeng, D., ... & Sun, B. (2023). HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. Cellular & Molecular Immunology, 20(4), 404-418.

Coskunpinar, E. M., Tur, S., Binici, N. C., & Songür, C. Y. (2023). Association of GABRG3, GABRB3, HTR2A gene variants with autism spectrum disorder. Gene, 870, 147399.

Zhao, J., Xu, L., Chang, C., Jiang, P., Wei, K., Shi, Y., ... & He, D. (2022). Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis. Frontiers in Immunology, 13, 1054451.

Owaki, T., Kamimura, K., Ko, M., Nagayama, I., Nagoya, T., Shibata, O., ... & Terai, S. (2022). Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A. Disease Models & Mechanisms, 15(7), dmm049612.

Guest, N. S., Corey, P., Tyrrell, P. N., & El-Sohemy, A. (2022). Effect of caffeine on endurance performance in athletes may depend on HTR2A and CYP1A2 genotypes. Journal of Strength and Conditioning Research, 36(9), 2486-2492.

Kao, C. F., Kuo, P. H., Yu, Y. W. Y., Yang, A. C., Lin, E., Liu, Y. L., & Tsai, S. J. (2020). Gene-based association analysis suggests association of htr2a with antidepressant treatment response in depressed patients. Frontiers in Pharmacology, 11, 1762.

Mattina, G. F., Samaan, Z., Hall, G. B., & Steiner, M. (2020). The association of HTR2A polymorphisms with obsessive-compulsive disorder and its subtypes: A meta-analysis. Journal of Affective Disorders, 275, 278-289.

Maltby, V. E., Lea, R. A., Burnard, S., Xavier, A., Van Cao, T., White, N., ... & Lechner-Scott, J. (2020). Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients. Scientific reports, 10(1), 22217.

Gomes, C. K. F., Vieira-Fonseca, T., Melo-Felippe, F. B., de Salles Andrade, J. B., Fontenelle, L. F., & Kohlrausch, F. B. (2018). Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: Influence of the STin2 polymorphism. Comprehensive psychiatry, 82, 1-6.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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