HTR2C

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.

5-hydroxytryptamine receptor 2C

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Behavioral fear response Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Feeding behavior Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Locomotory behavior Source: InterPro
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Regulation of appetite Source: UniProtKB
Regulation of corticotropin-releasing hormone secretion Source: UniProtKB
Regulation of nervous system process Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB

Cell membrane

Extracellular: 33-52
Helical: 53-78
Cytoplasmic: 79-89
Helical: 90-110
Extracellular: 111-127
Helical: 128-150
Cytoplasmic: 151-170
Helical: 171-193
Extracellular: 194-213
Helical: 214-235
Cytoplasmic: 236-311
Helical: 312-333
Extracellular: 334-348
Helical: 349-371
Cytoplasmic: 372-458

N-glycosylated.