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Rabbit Anti-HTR2C Recombinant Antibody (CBLQ5-025) (CBMAB-1978CQ)

This product is a rabbit monoclonal antibody that recognizes HTR2C. The antibody CBLQ5-025 can be used for immunoassay techniques such as: WB.
See all HTR2C antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLQ5-025
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 2C
Introduction
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.
Entrez Gene ID
3358
UniProt ID
P28335
Alternative Names
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Biological Process
Behavioral fear response Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Feeding behavior Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Locomotory behavior Source: InterPro
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of fat cell differentiation Source: Ensembl
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Regulation of appetite Source: UniProtKB
Regulation of corticotropin-releasing hormone secretion Source: UniProtKB
Regulation of nervous system process Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 33-52
Helical: 53-78
Cytoplasmic: 79-89
Helical: 90-110
Extracellular: 111-127
Helical: 128-150
Cytoplasmic: 151-170
Helical: 171-193
Extracellular: 194-213
Helical: 214-235
Cytoplasmic: 236-311
Helical: 312-333
Extracellular: 334-348
Helical: 349-371
Cytoplasmic: 372-458
PTM
N-glycosylated.

Lu, K., Hong, Y., Tao, M., Shen, L., Zheng, Z., Fang, K., ... & Liu, Y. (2023). Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C. EMBO molecular medicine, 15(1), e16364.

Konjevod, M., Sreter, K. B., Popovic-Grle, S., Lampalo, M., Tudor, L., Jukic, I., ... & Svob Strac, D. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13(5), 800.

Nakayama, J., Tan, L., Li, Y., Goh, B. C., Wang, S., Makinoshima, H., & Gong, Z. (2021). A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis. Elife, 10, e70151.

Yao, T., He, J., Cui, Z., Wang, R., Bao, K., Huang, Y., ... & Liu, T. (2021). Central 5-HTR2C in the control of metabolic homeostasis. Frontiers in Endocrinology, 12, 694204.

Yoo, E. S., Li, L., Jia, L., Lord, C. C., Lee, C. E., Birnbaum, S. G., ... & Liu, C. (2021). Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell reports, 37(7).

Levchenko, A., Vyalova, N. M., Nurgaliev, T., Pozhidaev, I. V., Simutkin, G. G., Bokhan, N. A., & Ivanova, S. A. (2020). NRG1, PIP4K2A, and HTR2C as potential candidate biomarker genes for several clinical subphenotypes of depression and bipolar disorder. Frontiers in genetics, 11, 936.

Grubor, M., Zivkovic, M., Sagud, M., Nikolac Perkovic, M., Mihaljevic-Peles, A., Pivac, N., ... & Svob Strac, D. (2020). HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms and extrapyramidal side effects in haloperidol-treated patients with schizophrenia. International Journal of Molecular Sciences, 21(7), 2345.

Liu, Z., Gao, W., & Xu, Y. (2022). Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats. Bioengineered, 13(5), 11718-11731.

Puangpetch, A., Srisawasdi, P., Unaharassamee, W., Jiratjintana, N., Vanavanan, S., Punprasit, S., ... & Kroll, M. H. (2019). Association between polymorphisms of LEP, LEPR, DRD2, HTR2A and HTR2C genes and risperidone-or clozapine-induced hyperglycemia. Pharmacogenomics and Personalized Medicine, 155-166.

Puangpetch, A., Unaharassamee, W., Jiratjintana, N., Koomdee, N., & Sukasem, C. (2018). Genetic polymorphisms of HTR2C, LEP and LEPR on metabolic syndromes in patients treated with atypical antipsychotic drugs. Journal of Pharmacy and Pharmacology, 70(4), 536-542.

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For research use only. Not intended for any clinical use.

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