KANK1

KANK1 belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mut

KN Motif And Ankyrin Repeat Domains 1

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457).
Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457).
Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457).
Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457).

Actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Glomerular visceral epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of insulin receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of lamellipodium morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ruffle assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of wound healingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of establishment of cell polarityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB

Cell projection, ruffle membrane; Cytoplasm; Nucleus. Colocalizes with KIF21A in membrane ruffles (PubMed:19559006).
Shuttles between the cytoplasm and nucleus (PubMed:16968744).
Isoform 1&2: Cytoplasm; Nucleus. Shuttles between the cytoplasm and nucleus.

Cerebral palsy, spastic quadriplegic 2 (CPSQ2):
A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly.