KCNH6

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Full Name

potassium voltage-gated channel, subfamily H (eag-related), member 6

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity).
Channel properties may be modulated by cAMP and subunit assembly.

Biological Process

Membrane repolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIBA:GO_Central

Topology

Cytoplasmic: 1-261
Helical: 262-282
Extracellular: 283-298
Helical: 299-319
Cytoplasmic: 320-340
Helical: 341-361
Extracellular: 362-370
Helical: 371-391
Cytoplasmic: 392-398
Helical: 399-419
Extracellular: 420-463
Pore-forming: 464-484
Extracellular: 485-490
Helical: 491-511
Cytoplasmic: 512-994