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Mouse Anti-KCNH6 Recombinant Antibody (3D9) (CBMAB-A4638-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D9
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
KCNH6 (AAH06334, 1 a.a. ~ 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 6
Introduction
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]
Entrez Gene ID
81033
UniProt ID
Q9H252
Alternative Names
ERG2; HERG2; Kv11.2
Function
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity).
Channel properties may be modulated by cAMP and subunit assembly.
Biological Process
Membrane repolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIBA:GO_Central
Topology
Cytoplasmic: 1-261
Helical: 262-282
Extracellular: 283-298
Helical: 299-319
Cytoplasmic: 320-340
Helical: 341-361
Extracellular: 362-370
Helical: 371-391
Cytoplasmic: 392-398
Helical: 399-419
Extracellular: 420-463
Pore-forming: 464-484
Extracellular: 485-490
Helical: 491-511
Cytoplasmic: 512-994
More Infomation

ZHAO, R., LU, J., & XIONG, F. (2023). 1597-P: KCNH6 Regulates Hepatic Mitochondrial Function and Glucose Metabolism via NF-κB Pathway. Diabetes, 72(Supplement_1).

Lu, J., Shi, T. T., Yuan, S. S., Xie, R. R., Zhao, R. X., Zhu, J. J., & Yang, J. K. (2022). Cisapride induced hypoglycemia via the KCNH6 potassium channel. Frontiers in Endocrinology, 13, 1011238.

Zhang, Y. C., Xiong, F. R., Cheng, C., Shen, H., Zhao, R. X., Zhu, J. J., ... & Yang, J. K. (2022). KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca 2+ Regulation and Oxidative Stress Inhibition. Oxidative Medicine and Cellular Longevity, 2022.

Zhao, M. M., Lu, J., Li, S., Wang, H., Cao, X., Li, Q., ... & Yang, J. K. (2021). Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature communications, 12(1), 5616.

Zhang, J. X., Huang, P. J., Wang, D. P., Yang, W. Y., Lu, J., Zhu, Y., ... & Wang, R. L. (2021). m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Molecular Therapy, 29(12), 3436-3448.

Lu, J., Shen, H., Li, Q., Xiong, F., Xie, R., Yuan, M., & Yang, J. K. (2020). KCNH6 protects pancreatic β‐cells from endoplasmic reticulum stress and apoptosis. The FASEB Journal, 34(11), 15015-15028.

Lu, J., Shen, H., Li, Q., Xiong, F. R., Yuan, M. X., & Yang, J. K. (2020). Effect of KCNH6 on hepatic endoplasmic reticulum stress and glucose metabolism. Hormone and Metabolic Research, 52(09), 669-675.

Lu, J., Zhang, L., & Shi, T. T. (2020). 1854-P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress. Diabetes, 69(Supplement_1).

Yang, J. K., Lu, J., Yuan, S. S., Cao, X., Qiu, H. Y., Shi, T. T., ... & Xu, A. (2018). From hyper-to hypoinsulinemia and diabetes: effect of KCNH6 on insulin secretion. Cell Reports, 25(13), 3800-3810.

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For research use only. Not intended for any clinical use.

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