Mouse Anti-KCNH6 Recombinant Antibody (3D9) (CBMAB-A4638-LY)

Name: Mouse Anti-KCNH6 Recombinant Antibody (3D9)
SKU: CBMAB-A4638-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3D9

Application

ELISA

Immunogen

KCNH6 (AAH06334, 1 a.a. ~ 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium voltage-gated channel, subfamily H (eag-related), member 6

Introduction

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Entrez Gene ID

81033

UniProt ID

Q9H252

Alternative Names

ERG2; HERG2; Kv11.2

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity).
Channel properties may be modulated by cAMP and subunit assembly.

Biological Process

Membrane repolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIBA:GO_Central

Topology

Cytoplasmic: 1-261
Helical: 262-282
Extracellular: 283-298
Helical: 299-319
Cytoplasmic: 320-340
Helical: 341-361
Extracellular: 362-370
Helical: 371-391
Cytoplasmic: 392-398
Helical: 399-419
Extracellular: 420-463
Pore-forming: 464-484
Extracellular: 485-490
Helical: 491-511
Cytoplasmic: 512-994

ZHAO, R., LU, J., & XIONG, F. (2023). 1597-P: KCNH6 Regulates Hepatic Mitochondrial Function and Glucose Metabolism via NF-κB Pathway. Diabetes, 72(Supplement_1).

Lu, J., Shi, T. T., Yuan, S. S., Xie, R. R., Zhao, R. X., Zhu, J. J., & Yang, J. K. (2022). Cisapride induced hypoglycemia via the KCNH6 potassium channel. Frontiers in Endocrinology, 13, 1011238.

Zhang, Y. C., Xiong, F. R., Cheng, C., Shen, H., Zhao, R. X., Zhu, J. J., ... & Yang, J. K. (2022). KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca 2+ Regulation and Oxidative Stress Inhibition. Oxidative Medicine and Cellular Longevity, 2022.

Zhao, M. M., Lu, J., Li, S., Wang, H., Cao, X., Li, Q., ... & Yang, J. K. (2021). Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature communications, 12(1), 5616.

Zhang, J. X., Huang, P. J., Wang, D. P., Yang, W. Y., Lu, J., Zhu, Y., ... & Wang, R. L. (2021). m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Molecular Therapy, 29(12), 3436-3448.

Lu, J., Shen, H., Li, Q., Xiong, F., Xie, R., Yuan, M., & Yang, J. K. (2020). KCNH6 protects pancreatic β‐cells from endoplasmic reticulum stress and apoptosis. The FASEB Journal, 34(11), 15015-15028.

Lu, J., Shen, H., Li, Q., Xiong, F. R., Yuan, M. X., & Yang, J. K. (2020). Effect of KCNH6 on hepatic endoplasmic reticulum stress and glucose metabolism. Hormone and Metabolic Research, 52(09), 669-675.

Lu, J., Zhang, L., & Shi, T. T. (2020). 1854-P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress. Diabetes, 69(Supplement_1).

Yang, J. K., Lu, J., Yuan, S. S., Cao, X., Qiu, H. Y., Shi, T. T., ... & Xu, A. (2018). From hyper-to hypoinsulinemia and diabetes: effect of KCNH6 on insulin secretion. Cell Reports, 25(13), 3800-3810.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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