KL

The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

KLOTHO

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity).
Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Acute inflammatory responseIEA:Ensembl
AgingManual Assertion Based On ExperimentIMP:UniProtKB
Calcium ion homeostasisIEA:Ensembl
Carbohydrate metabolic processIEA:InterPro
Energy reserve metabolic processIEA:Ensembl
Fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Insulin receptor signaling pathwayIEA:InterPro
Negative regulation of systemic arterial blood pressureIEA:Ensembl
Norepinephrine biosynthetic processIEA:Ensembl
Positive regulation of bone mineralizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Response to activityIEA:Ensembl
Response to angiotensinIEA:Ensembl
Response to vitamin DIEA:Ensembl

Isoform 1: Cell membrane; Apical cell membrane. Isoform 1 shedding leads to a soluble peptide.
Isoform 2: Secreted
Klotho peptide: Secreted