KLRA6

Klra6 belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. Klra6 is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences.

Killer Cell Lectin-Like Receptor, Subfamily A, Member 6

Receptor on natural killer (NK) cells for class I MHC.

Cell adhesionIEA:UniProtKB-KW

Membrane

Cytoplasmic: 1-44
Helical: 45-66
Extracellular: 67-266