LAMTOR5

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx).

Full Name

Late Endosomal/Lysosomal Adaptor, Mapk And Mtor Activator 5

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Biological Process

Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA bindingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of TORC1 signalingManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell sizeManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentTAS:ProtInc
Viral genome replicationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Lysosome
Cytoplasm, cytosol